Skip to main content Accessibility help
×
Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-23T05:57:44.507Z Has data issue: false hasContentIssue false

Debate 11B - Should an Attempt at Aggressive Cytoreduction be Made for all Surgical Candidates with Advanced Ovarian Cancer prior to Treatment with Adjuvant Chemotherapy?

No

from Section III - Ovarian Cancer

Published online by Cambridge University Press:  20 July 2023

Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
Get access

Summary

The concept that aggressive cytoreduction attempts be made for all surgical candidates does not seem to be a realistic goal as evidenced by recent publications. There is no doubt that primary surgery has an important role, but equally so does neo-adjuvant chemotherapy. The latter approach is evidence based, showing similar survival patterns but less morbidities and postsurgical in-patient stay. However, randomized trials where the evidence is contrary to accepted practise often generate heated criticisms, others fitting beliefs are applauded. It is welcome that there is an ongoing trial addressing primary surgery, and hopefully this will contribute in identifying those where aggressive primary surgery is best employed. The survival for advanced ovarian cancer remains poor, and rather than considering a single approach as optimum, strategies to individualize treatments and examine novel therapeutic approaches seems a more logical way to improve survival rates.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Searle, Gemma, et al. Prolonged interruption of chemotherapy in patients undergoing delayed debulking surgery for advanced high-grade serous ovarian cancer is associated with a worse prognosis. Gynecol Oncol 2020;158(1):5458. https://doi.org/10.1016/j.ygyno.2020.04.048CrossRefGoogle ScholarPubMed
Straubhar, AM, et al. A multimodality triage algorithm to improve cytoreductive outcomes in patients undergoing primary debulking surgery for advanced ovarian cancer: a Memorial Sloan Kettering Cancer Center team ovary initiative. Gynecol Oncol 2020;158(3):608613.CrossRefGoogle ScholarPubMed
Vergote, I, et al. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Group; NCIC Clinical Trials Group. Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med 2010;363(10):943953.CrossRefGoogle ScholarPubMed
Kehoe, S, et al. Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomized, controlled, non-inferiority trial. Lancet 2015;386(9990):249257.CrossRefGoogle Scholar
Ramirez, PT, et al. Minimally invasive versus abdominal radical hysterectomy for cervical cancer. N Engl J Med 2018;379(20):18951904. https://doi.org/10.1056/NEJMoa1806395CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×