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Three Cycles
from Section III - Ovarian Cancer
Published online by Cambridge University Press: 20 July 2023
High-risk stage I ovarian cancer includes clear cell and grade 3 tumours. ESMO–ESGO guidelines suggests carboplatin in monotherapy for six cycles or the combination of carboplatin and paclitaxel for a minimum of three cycles as available options for adjuvant treatment in this setting. Nevertheless, there is not a study that compare the two options. On the basis of data available, three cycles of carboplatin plus paclitaxel represents an effective strategy to reduce the probability of recurrence in high-risk early-stage ovarian cancer patients, especially in non-serous tumors. Three cycles compared with six cycles of carboplatin and paclitaxel do not significantly alter the recurrence rate in high-risk ovarian cancer, but six cycles are associated with more toxicity.
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