The Isaac Newton Institute of Mathematical Sciences at the University of Cambridge exists to stimulate research in all branches of the mathematical sciences, including pure mathematics, statistics, applied mathematics, theoretical physics, theoretical computer science, mathematical biology and economics. The four six-month long research programmes it runs each year bring together leading mathematical scientists from all over the world to exchange ideas through seminars, teaching and informal interaction. Associated with the programmes are two types of publication. The first contains lecture courses, aimed at making the latest developments accessible to a wider audience and providing an entry to the area. The second contains proceedings of workshops and conferences focusing on the most topical aspects of the subjects.