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  3. Cancer: Clinical Science in Practice

The study of cancer has progressed rapidly in recent years as a result of new molecular and genetic techniques. This series sets out to provide an authoritative collection of volumes covering the broad range of issues at the interface between basic science and clinical practice in medical and surgical oncology. Topics covered will range from molecular mechanisms through to the scientific aspects of clinical managements, with an emphasis on innovation in diagnosis and treatment.

  • Edited by: Karol Sikora, Royal Postgraduate Medical School

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2 results in Cancer: Clinical Science in Practice

Gene Therapy in the Treatment of Cancer
  • Progress and Prospects
  • Edited by Brian E. Huber, Ian Magrath
  • Published online:
    01 April 2010
    Print publication:
    24 September 1998
  • The clinical applications of human gene therapy have been particularly fruitful in oncology, and in the last few decades there has been explosive growth in understanding of the genetic lesions leading to neoplasia. This volume in the series Cancer: Clinical Science in Practice reviews progress in the basic and clinical science of gene therapy in oncology, and looks forward to future developments. It considers what has worked and what has not in the fast-evolving field of gene therapy, drawing on laboratory studies and clinical trials, including the work of the contributors themselves. Topical and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.

Drug Resistance in the Treatment of Cancer
  • Herbert M. Pinedo, Giuseppe Giaccone
  • Foreword by Karol Sikora
  • Published online:
    14 October 2009
    Print publication:
    26 March 1998
  • The development of drug-resistant cancers is considered to be the most significant obstacle to the cure of cancer today. Nearly half of all patients with cancer suffer from tumours that are intrinsically resistant to chemotherapy, and most of the remaining half develop drug resistance during the course of their treatment. This book reviews the mechanisms and clinical implications of drug resistance in cancer with unrivalled authority. Chapters cover topics of current clinical concern, including multiple drug resistance and its reversal, topoisomerase drugs, apoptosis, dose intensity and escalation, gene therapy and haematopoietic support. The authors are among the leading clinicians and investigators in the field. These authoritative volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.