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  3. Cambridge Studies in Mathematical Biology

Books in this series are concerned with mathematical aspects of biology or mathematical treatments of areas in the biological sciences suitable for such approaches. The series is aimed at undergraduate and graduate students, especially those taking courses in mathematical biology. Each book will be reasonably self-contained, covering necessary background theory, but without allowing the mathematical details to obscure biological relevance. Books will be properly edited and typeset: a liberal paperbacking policy is pursued.

  • General Editors: C. Cannings, University of Sheffield, F. C. Hoppensteadt, Michigan State University, L. A. Segel

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11 results in Cambridge Studies in Mathematical Biology

Mathematics of Genome Analysis
  • Jerome K. Percus
  • Published online:
    04 December 2009
    Print publication:
    03 December 2001
  • The massive research effort known as the Human Genome Project is an attempt to record the sequence of the three trillion nucleotides that make up the human genome and to identify individual genes within this sequence. While the basic effort is of course a biological one, the description and classification of sequences also lend themselves naturally to mathematical and statistical modeling. This short textbook on the mathematics of genome analysis presents a brief description of several ways in which mathematics and statistics are being used in genome analysis and sequencing. It will be of interest not only to students but also to professional mathematicians curious about the subject.

An Introduction to Mathematical Physiology and Biology
  • 2nd edition
  • J. Mazumdar
  • Published online:
    05 June 2012
    Print publication:
    19 August 1999
  • This textbook is concerned with the mathematical modelling of biological and physiological phenomena for mathematically sophisticated students. A range of topics are discussed: diffusion population dynamics, autonomous differential equations and the stability of ecosystems, biogeography, pharmokinetics, biofluid mechanics, cardiac mechanics, the spectral analysis of heart sounds using FFT techniques. The last chapter deals with a wide variety of commonly used medical devices. This book is based on courses taught by the author over many years and the material is well class tested. The reader is aided by many exercises that examine key points and extend the presentation in the body of the text. All students of mathematical biology will find this book to be a highly useful resource.

Epidemic Modelling
  • An Introduction
  • D. J. Daley, J. Gani
  • Published online:
    16 November 2009
    Print publication:
    13 April 1999
  • This general introduction to the ideas and techniques required for the mathematical modelling of diseases begins with an outline of some disease statistics dating from Daniel Bernoulli's 1760 smallpox data. The authors then describe simple deterministic and stochastic models in continuous and discrete time for epidemics taking place in either homogeneous or stratified (non-homogeneous) populations. Several techniques for constructing and analysing models are provided, mostly in the context of viral and bacterial diseases of human populations. These models are contrasted with models for rumours and vector-borne diseases like malaria. Questions of fitting data to models, and their use in understanding methods for controlling the spread of infection, are discussed. Exercises and complementary results at the end of each chapter extend the scope of the text, which will be useful for students taking courses in mathematical biology who have some basic knowledge of probability and statistics.

The Theory of the Chemostat
  • Dynamics of Microbial Competition
  • Hal L. Smith, Paul Waltman
  • Published online:
    07 December 2009
    Print publication:
    27 January 1995
  • The chemostat is a basic piece of laboratory apparatus, yet it has occupied an increasingly central role in ecological studies. The ecological environment created by a chemostat is one of the few completely controlled experimental systems for testing microbial growth and competition. As a tool in biotechnology, the chemostat plays an important role in bioprocessing. This book presents the theory of the chemostat as a model for larger ecological problems such as food chains, competition along a gradient, competition in the presence of an inhibitor, and the effects of time varying inputs. Models which take account of size structure, variable yields, and diffusion are also considered. The basic phenomena are modelled and analysed using the dynamical systems approach. Directions for research and open problems are discussed. Six appendices provide an elementary description of the necessary mathematical tools. Teachers, researchers, and students in applied mathematics, chemical engineering and ecology will find this book a welcome resource.

Evolution in Age-Structured Populations
  • 2nd edition
  • Brian Charlesworth
  • Published online:
    18 December 2009
    Print publication:
    30 June 1994
  • The populations of many species of animals and plants are age-structured, i.e. the individuals present at any one time were born over a range of different times, and their fertility and survival depend on age. The properties of such populations are important for interpreting experiments and observations on the genetics of populations for animal and plant breeding, and for understanding the evolution of features of life-histories such as senescence and time of reproduction. In this new edition Brian Charlesworth provides a comprehensive review of the basic mathematical theory of the demography and genetics of age-structured populations. The mathematical level of the book is such that it will be accessible to anyone with a knowledge of basic calculus and linear algebra.

Modelling Biological Populations in Space and Time
  • Eric Renshaw
  • Published online:
    05 August 2012
    Print publication:
    26 July 1991
  • This volume develops a unifying approach to population studies, emphasising the interplay between modelling and experimentation. Throughout, mathematicians and biologists are provided with a framework within which population dynamics can be fully explored and understood. Aspects of population dynamics covered include birth-death and logistic processes, competition and predator-prey relationships, chaos, reaction time-delays, fluctuating environments, spatial systems, velocities of spread, epidemics, and spatial branching structures. Both deterministic and stochastic models are considered. Whilst the more theoretically orientated sections will appeal to mathematical biologists, the material is presented so that readers with little mathematical expertise can bypass these without losing the main flow of the text.

Introduction to Theoretical Neurobiology
  • Volume 2, Nonlinear and Stochastic Theories
  • Henry C. Tuckwell
  • Published online:
    27 January 2010
    Print publication:
    29 April 1988
  • The second part of this two-volume set contains advanced aspects of the quantitative theory of the dynamics of neurons. It begins with an introduction to the effects of reversal potentials on response to synaptic input. It then develops the theory of action potential generation based on the seminal Hodgkin-Huxley equations and gives methods for their solution in the space-clamped and non-space-clamped cases. The remainder of the book discusses stochastic models of neural activity and ends with a statistical analysis of neuronal data with emphasis on spike trains. The mathematics is more complex in this volume than in the first volume and involves numerical methods of solution of partial differential equations and the statistical analysis of point processes.

Introduction to Theoretical Neurobiology
  • Volume 1, Linear Cable Theory and Dendritic Structure
  • Henry C. Tuckwell
  • Published online:
    29 December 2009
    Print publication:
    29 April 1988
  • The human brain contains billions of nerve cells whose activity plays a critical role in the way we behave, feel, perceive, and think. This two-volume set explains the basic properties of a neuron - an electrically active nerve cell - and develops mathematical theories for the way neurons respond to the various stimuli they receive. Volume 1 contains descriptions and analyses of the principal mathematical models that have been developed for neurons in the past thirty years. It provides a brief review of the basic neuroanatomical and neurophysiological facts that will form the focus of the mathematical treatment. Tuckwell discusses the mathematical theories, beginning with the theory of membrane potentials. He then goes on to treat the Lapicque model, linear cable theory, and time-dependent solutions of the cable equations. He concludes with a description of Rall's model nerve cell. Because the level of mathematics increases steadily upward from Chapter Two, some familiarity with differential equations and linear algebra is desirable.

Mathematical Aspects of Hodgkin-Huxley Neural Theory
  • Jane Cronin
  • Published online:
    05 November 2011
    Print publication:
    28 August 1987
  • This book is an introduction to the study of mathematical models of electrically active cells, which play an essential role in, for example, nerve conduction and cardiac functions. This is an important and vigorously researched field. In the book, Dr Cronin synthesizes and reviews this material and provides a detailed discussion of the Hodgkin-Huxley model for nerve conduction, which forms the cornerstone of this body of work. Her treatment includes a derivation of the Hodgkin-Huxley model, which is a system of four nonlinear differential equations; a discussion of the validity of this model; and a summary of some of the mathematical analysis carried out on this model. Special emphasis is placed on singular perturbation theory, and arguments, both mathematical and physiological, for using the perturbation viewpoint are presented.

Mathematical Methods of Population Biology
  • Frank C. Hoppensteadt
  • Published online:
    04 May 2010
    Print publication:
    26 February 1982
  • This introduction to mathematical methods that are useful for studying population phenomena is intended for advanced undergraduate and graduate students, and will be accessible to scientists who do not have a strong mathematics background. The material is graded in mathematical difficulty. The earlier parts of the book involve elementary diference equations while later chapters present topics that require more mathematical preparation. Models of total population and population age structure are first derived and studied, and then models of random population events are presented in terms of Markov chains. The last two chapters deal with mathematical methods used to uncover qualitative behaviour of more complicated difference equations. Each chapter begins with a simple model, usually of some historical interest, that defines the primary goals of the chapter. Exercises, for which solutions are provided, illustrate material in the text and also deal with models more advanced than those derived and studied in the text.

Mechanics of Swimming and Flying
  • Stephen Childress
  • Published online:
    06 July 2010
    Print publication:
    31 July 1981
  • This book provides a clear and concise summary of the fluid dynamics of the locomotion of living organisms. The biological phenomena described in detail range from the swimming of bacteria and fish to the flying of insects and birds. The breadth of treatment requires the study of two basic fluid-dynamical regimes. In the first case, that of small organisms, the viscosity of the fluid is paramount in deciding the most effective swimming strategy. However, for larger insects, birds, and most fish, the viscosity of the air or water may be treated as if it were zero, and resulting mechanisms of propulsion are very different. Both these types are studied, with emphasis on the unsteady character of natural movements. Written for the advanced student, this volume assumes familiarity with basic fluid mechanics, although some elementary topics are included. It will be readily accessible to students of applied mathematics and biologists who have engineering or physics backgrounds.