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Systems genetics is the study of DNA sequence variation and biological traits as a complex system characterized by spatial and temporal interactions. This includes phenomena such as epigenetics, epistasis, plastic reaction norms, and locus heterogeneity. The Cambridge Series in Systems Genetics covers all areas of genetics approached from a complex systems point of view. This series is of interest to researchers across several areas of the life sciences including bioinformatics, evolution, genomics, human genetics, molecular genetics, precision medicine, and systems biology.

  • General Editors: Jason H. Moore, University of Pennsylvania, Scott M. Williams, Case Western Reserve University, Ohio

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1 results in Cambridge Series in Systems Genetics

Systems Genetics
  • Linking Genotypes and Phenotypes
  • Edited by Florian Markowetz, Michael Boutros
  • Published online:
    05 July 2015
    Print publication:
    02 July 2015
  • Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.