This manuscript showcases the latest advancements in deepImageJ, a pivotal Fiji/ImageJ plugin for bioimage analysis in life sciences. The plugin, known for its user-friendly interface, facilitates the application of diverse pre-trained convolutional neural networks to custom data. The manuscript demonstrates several deepImageJ capabilities, particularly in deploying complex pipelines, three-dimensional (3D) image analysis, and processing large images. A key development is the integration of the Java Deep Learning Library, expanding deepImageJ’s compatibility with various deep learning (DL) frameworks, including TensorFlow, PyTorch, and ONNX. This allows for running multiple engines within a single Fiji/ImageJ instance, streamlining complex bioimage analysis workflows. The manuscript details three case studies to demonstrate these capabilities. The first case study explores integrated image-to-image translation followed by nuclei segmentation. The second case study focuses on 3D nuclei segmentation. The third case study showcases large image volume segmentation and compatibility with the BioImage Model Zoo. These use cases underscore deepImageJ’s versatility and power to make advanced DLmore accessible and efficient for bioimage analysis. The new developments within deepImageJ seek to provide a more flexible and enriched user-friendly framework to enable next-generation image processing in life science.

Consider a flow in $\mathbb{R}^3$ and let K be the biggest invariant subset of some compact region of interest $N \subseteq \mathbb{R}^3$. The set K is often not computable, but the way the flow crosses the boundary of N can provide indirect information about it. For example, classical tools such as Ważewski’s principle or the Poincaré–Hopf theorem can be used to detect whether K is non-empty or contains rest points, respectively. We present a criterion that can establish whether K has a non-trivial homology by looking at the subset of the boundary of N along which the flow is tangent to N. We prove that the criterion is as sharp as possible with the information it uses as an input. We also show that it is algorithmically checkable.

This paperpresents the measurement procedure as well as the calculations and theoretical background for the estimation of particle sizes with the help of a dual-frequency measurement setup. For the measurement, two fully integrated radar sensors are implemented which offer advantages over typically used technologies at high frequencies. The first sensor has a constant transmitting frequency of 90 GHz while the second sensor offers a possibility to vary the transmitting frequency over the entire D-band with frequencies between 110 and 180 GHz. With these frequencies, different sizes can be determined. The presented approach makes use of the different transitions between the linear increasing Rayleigh scattering regime and the Mie regime. With a fitting indoor measurement setup that resembles an industrial duct, the approach is verified for spheroid glass particles with a diameter of 0.875 mm. The results show a slight deviation from the expected value of particle sizes overall.

The agency of a person with young onset dementia (YOD) changes owing to individual symptoms, uncertainty about the speed of progression and the severity of YOD. Dementia usually greatly interrupts life and reduces agency. Previous studies show that some people and families integrate and cope with dementia better than others. This study aimed to find out how YOD changes the agency of the person who has it and what family members’ role is in forming their agency. The data were collected in Finland in semi-structured interviews with 14 people with YOD and 15 family members, about a year after the diagnosis. These two data sets were analysed with a narrative method, actantial analysis. A wide variety of elements, both human and non-human factors, were found to promote and undermine agency. It was found that people with YOD need both integrity and flexibility to reconstruct their own agency. Resources support them in this process of reconstruction, and hinderers interrupt the process. This combination of integrity and flexibility, resources and hinderers, generates how people with YOD recount the future, the aims they set and how they reconstruct their agency. Other people, especially family members, are part of this dynamic process and when their relationship is cohesive, the agency of both parties increases. The participants used ideal and burdensome storylines to narrate factors that supported or interrupted their agency. Based on our findings, narrating one’s situation is, for coping, not only a means but its very basis.

In this work, we are interested in studying the following class of problems:(𝒫λμ)

\begin{align}\left\{\begin{array}{ll}-\Delta u=f_\lambda(x,u,v)& \text{in}~~\Omega\\-\Delta v=g_\mu(x,u,v) & \text{in}~~\Omega\\0\not\equiv u\geq 0,\,\,0\not\equiv v\geq 0& \text{in}~~\Omega\\u=v=0&\text{on}~~\partial\Omega\end{array}\right.\end{align}

$\mathbb{R}^N$

$t\mapsto f_\lambda(x,t,t)$

$t\mapsto g_\mu(x,t,t)$

$(\mathcal{P}_{\lambda\mu})$

This article discusses the relationship between particular and general customary international law, grappling with academic views affirming that, ordinarily, the emergence of the former is a stage in the consolidation of the latter. It is argued that the higher standard of State consent required for the configuration of bilateral or regional custom suggests otherwise. In addition, it is also contended that a distinctive kind of opinio juris must be present for particular custom to arise: a conviction from the States concerned that their conduct is governed by particular (as opposed to general) customary law.

This study uses a rational choice approach to argue that an under-theorized and rarely tested cause of governmental discrimination against religious minorities is its popularity. Specifically, we argue that self-interested politicians are more likely to enact discriminatory policies when they believe said discrimination will be popular. These policies, in turn, have payoffs via increased public perceptions of governmental legitimacy. Using the Religion and State project, round 3 and World Values Survey data for members of the majority religion between 1990 and 2014 in 58 Christian-majority countries, we demonstrate that prejudice against members of other religions predicts increased governmental religious discrimination, which is, in turn, associated with higher confidence in government, legislatures, and political parties. While our results are specific to discrimination against religious minorities, this suggests that when discrimination against minorities in general is popular, politicians are likely to oblige.

The propagation paths of oceanic internal tides are influenced by their interactions with vortices. We examine the scattering effect that an isolated vortex in (cyclo)geostrophic balance has on a rotating shallow-water plane wave. We run a suite of simulations in which we vary the non-dimensional vorticity of the vortex, $Ro$, the relative scale of the vortex size to the Rossby radius of deformation, $Bu$, and the size of the vortex compared with the plane wave wavelength, $K$. We compare the scattered wave flux pattern with ray-tracing predictions. Ray-tracing predictions are relatively insensitive to $K$ in the $1< K<4$ range we investigate; however, they generally underestimate the broad angles of the shallow-water wave scattering patterns, especially for the lower end of the $K$ range. We then measure the ratio of the scattered wave energy flux to the incoming wave energy flux, denoted by $S$, for each simulation. We find that $S$ follows a power law $S \propto (FrK)^2$ when $S < 0.2$, where $Fr = Ro/\sqrt {Bu}$ is the Froude number. When $S>0.2$, it starts plateauing.

The gas dynamics of shock-induced gas filtration through densely packed granular columns with vastly varying shock intensity and the structural parameters are numerically investigated using a coupled Eulerian–Lagrangian approach. The results shed fundamental light on the thermal effects of the shock-induced gas filtration manifested by a distinctive self-heating hot gas layer traversing the medium. The characteristics of the thermal effects in terms of the thermal intensity and uniformity are found to vary with the shock Mach number, Ms, and the filtration coefficient of the granular media, Π. As the incident shock transitions from weak to strong, and (or) the filtration coefficient increases from O(10−5) to O(104), the heating mechanisms transition between three distinct heating modes. A phase diagram of heating modes is established on the parameter space (Ms, Π), which enables us to predict the characteristics of the thermal effect in different shock-induced gas filtrations. The thermal effects markedly accelerate the pressure diffusion due to the additional heat influx when the time scale of the former is smaller than or comparable to the latter. Based on the contour map displaying the coupling degree of the thermal effects and the pressure diffusion, we identify a decoupling criterion whereby the isothermal assumption holds if only the pressure diffusion is concerned. The thermal effects may well bring about considerable thermal shocks which pose a great threat to the integrity of the solid skeleton and further reduce the overall shock resistance performance of the porous media.

Increasingly, governments report on public service quality, which has the potential to inform evaluations of performance that underlie voters’ opinions and behaviors. We argue these policies have important effects that go beyond informing voters. Specifically, we contend that the format in which policymakers choose to report information will steer the direction of opinion by exacerbating or mitigating biases in information processing. Using the case of school accountability systems in the United States and a variety of experimental and observational approaches, we find that letter grade systems for rating public school performance, as opposed to other reporting formats, exacerbate negativity bias. Public opinion proves more responsive to negative information than to positive information in letter grade systems than in alternate formats. Policymakers, then, do not simply inform public opinion; rather, their decisions about how to present information shape the interpretations that voters ultimately draw from the information provided.

Biodiversity shortfalls and taxonomic bias can lead to inaccurate assessment of conservation priorities. Previous literature has begun to explore practical reasons why some species are discovered sooner or are better researched than others. However, the deeper socio-cultural causes for undiscovered and neglected biodiversity, and the value of collectively analysing species at risk of unrecorded, or “dark”, extinction, are yet to be fully examined. Here, we argue that a new label (we propose “shadow diversity”) is needed to shift our perspective from biodiversity shortfalls to living, albeit unknown, species. We suggest this linguistic shift imparts intrinsic value to these species, beyond scientific gaze and cultural systems. We review research on undiscovered, undetected and hidden biodiversity in the fields of conservation biology, macroecology and genetics. Drawing on philosophy, geography, history and sociology, we demonstrate that a range of socio-cultural factors (funding, education and historical bias) combine with traditional, practical impediments to limit species discovery and detection. We propose using a spectrum of shadow diversity which enables a complex, non-binary and comprehensive approach to biodiversity unknowns. Shadow diversity holds exciting potential as a tool to increase awareness, appreciation and support for the conservation of traditionally less studied wildlife species and sites, from soil microbes to less charismatic habitat fragments. We advocate for a shift in how the conservation community and wider public see biodiversity and an increase in popular support for conserving a wider range of life forms. Most importantly, shadow diversity provides appropriate language and conceptual frameworks to discuss species absent from conservation assessment and at potential risk of dark extinction.

We present a new proof of the compactness of bilinear paraproducts with CMO symbols. By drawing an analogy to compact linear operators, we first explore further properties of compact bilinear operators on Banach spaces and present examples. We then prove compactness of bilinear paraproducts with CMO symbols by combining one of the properties of compact bilinear operators thus obtained with vanishing Carleson measure estimates and interpolation of bilinear compactness.

Language variation is demonstrably affected by accumulated experiences reflecting the consequences of the contexts in which words are most frequently used. Yet, these contextual frequency effects are seldom explored in children’s speech. This study uses a corpus-based approach to investigate how 29 Spanish-speaking children, aged 5–15, realize word-initial Spanish /d/ as a function of accumulated experiences with /d/-initial words in articulatory contexts that promote reduction. Contextual frequency effects are also examined in 12 Spanish-speaking adults from the children’s community. Cumulative experience is estimated as the form’s frequency of occurrence in a specific context that promotes a specific variant. Results reveal contextual frequency effects in both the child and adult data. Moreover, the extent of the contextual frequency effect is comparable across generations.

Timing of food intake is an emerging aspect of nutrition; however, there is a lack of research accurately assessing food timing in the context of the circadian system. The study aimed to investigate the relation between food timing relative to clock time and endogenous circadian timing with adiposity and further explore sex differences in these associations among 151 young adults aged 18–25 years. Participants wore wrist actigraphy and documented sleep and food schedules in real time for 7 consecutive days. Circadian timing was determined by dim-light melatonin onset (DLMO). The duration between last eating occasion and DLMO (last EO-DLMO) was used to calculate the circadian timing of food intake. Adiposity was assessed using bioelectrical impedance analysis. Of the 151 participants, 133 were included in the statistical analysis finally. The results demonstrated that associations of adiposity with food timing relative to circadian timing rather than clock time among young adults living in real-world settings. Sex-stratified analyses revealed that associations between last EO-DLMO and adiposity were significant in females but not males. For females, each hour increase in last EO-DLMO was associated with higher BMI by 0·51 kg/m2 (P = 0·01), higher percent body fat by 1·05 % (P = 0·007), higher fat mass by 0·99 kg (P = 0·01) and higher visceral fat area by 4·75 cm2 (P = 0·02), whereas non-significant associations were present among males. The findings highlight the importance of considering the timing of food intake relative to endogenous circadian timing instead of only as clock time.

Cartels today are illegal and illegitimate across the globe. Yet until the end of World War II, cartels were legal, ubiquitous, and popular—especially in Europe. How, then, did cartels become bad, if they had been considered a positive force for capitalist stabilization and peace in the first half of the 20th century? That is the question this dissertation poses. By the 1930s, over 1,000 monopolistic agreements regulated nearly half of world trade. International cartels governed the interwar world economy, setting prices and output quotas, dividing world markets, regulating trade flows, and even controlling the transfer of patents across firms and sovereign state borders. I conceptualize this regime as “cartel capitalism.” Most cartels were headquartered in industrial Europe. First, I trace how a surprising consensus in interwar Europe—comprising national governments; international organizations like the League of Nations; industrialists, led by the International Chamber of Commerce; federalists; and even socialists—backed cartels as a panacea to the problems of reconstruction after 1918, namely the quest for peace and stable markets. However, in the wake of 1945, most countries in Western Europe—along with the new supranational European Coal and Steel Community (ECSC, 1951) and European Economic Community (EEC)—started prohibiting cartels. My project illuminates the causes and consequences of this great reversal. Monopoly Menace reveals, for the first time, how Europe’s transnational reckoning with the shocks of the Great Depression, fascism, and total war produced a genuine anticartel revolution that rewrote the rules of the modern European and global economy. Monopoly Menace ends by illuminating how American, British, French, and West German postwar planners designed new national welfare states, the Bretton Woods Order, and the European Union on the neglected foundation of anti-cartel policies.