‘Lemberger’ wine grape response was evaluated when chlorsulfuron, tribenuron, thifensulfuron, chlorsulfuron plus metsulfuron, thifensulfuron plus tribenuron, and 2,4-D were applied up to three times at weekly intervals in 1992 and 1993 at rates simulating drift. All herbicides injured grapevines visibly. Symptoms increased and total leaf area and grape pruning weight decreased as the herbicide rate and number of applications increased. Grapevines generally recovered within 45 to 60 d from symptoms caused by single exposures to low levels of sulfonylurea herbicides. Multiple exposures of grapevines to 2,4-D, tribenuron, and chlorsulfuron plus metsulfuron at 1/100 of the maximum use rate for wheat caused the greatest injury, which persisted throughout the entire growing season and reduced pruning weight. Based on potential use rate, the order of herbicide phytotoxicity was 2,4-D > tribenuron > chlorsulfuron plus metsulfuron > thifensulfuron plus tribenuron > chlorsulfuron > thifensulfuron. Rates that slightly injured grapevines did not reduce growth as measured by pruning weight. However, multiple exposure to high rates of 2,4-D, tribenuron, and chlorsulfuron plus metsulfuron adversely affected growth.