Socrates, the renowned philosopher, famously averred that “the beginning of wisdom is the definition of terms.” The veracity of that ageless quip is, of course, debatable from a rhetorical standpoint. The definition of terms may or may not mark the genesis of wisdom but, rest assured, conceptual reflection of term definitions indisputably constitutes a crucial early step in legal construction and interpretation. This chapter focuses on a simple, yet fundamental, question that remains unaddressed in modern literature: What exactly is genome editing? To that end, the chapter lays an interpretive and normative foundation that imports meaning into the term’s scope. It starts by highlighting how scientific literature has remarkably devoted substantial efforts to discuss ways to develop, use, improve, and expand the technology without actually attaching a particular meaning to the term. After exposing limitations associated with the use of dictionaries in legal analysis, the chapter argues that congruity and uniformity on genome-editing terminology is sorely needed now due to the increasing interdisciplinary reach of the technology. Accordingly, it advocates for the adoption of a unified definition of genome editing. The proposed definition undergoes rigorous analysis and, along the way, the chapter dispels the myth that law generally lags behind scientific progress.