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tumour model

European Journal of Applied Mathematics (1)

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Stability and bifurcation analysis of a free boundary problem modelling multi-layer tumours with Gibbs–Thomson relation
FUJUN ZHOU, JUNDE WU
Journal:

European Journal of Applied Mathematics / Volume 26 / Issue 4 / August 2015

Published online by Cambridge University Press:

10 April 2015, pp. 401-425
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Of concern is the stability and bifurcation analysis of a free boundary problem modelling the growth of multi-layer tumours. A remarkable feature of this problem lies in that the free boundary is imposed with nonlinear boundary conditions, where a Gibbs–Thomson relation is taken into account. By employing a functional approach, analytic semigroup theory and bifurcation theory, we prove that there exists a positive threshold value γ* of surface tension coefficient γ such that if γ > γ* then the unique flat stationary solution is asymptotically stable under non-flat perturbations, while for γ < γ* this unique flat stationary solution is unstable and there exists a series of non-flat stationary solutions bifurcating from it. The result indicates a significant phenomenon that a smaller value of surface tension coefficient γ may make tumours more aggressive.

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Stability and bifurcation analysis of a free boundary problem modelling multi-layer tumours with Gibbs–Thomson relation

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Stability and bifurcation analysis of a free boundary problem modelling multi-layer tumours with Gibbs–Thomson relation