This article considers Juana Manso (1819–1875) as a crucial nation maker in nineteenth-century Argentina. Usually studied as a novelist, Manso was important beyond her literary production. As the first woman to be appointed to a government position and arguably the most radical feminist in nineteenth-century Argentina, Manso's story informs us about Argentine feminism and education, and illustrates how a woman, who lived in Uruguay, Brazil, United States and Cuba, became a crucial transmitter of ideas about emerging nations and a living example of the interconnectedness of the Americas.