The heliosphere is the region filled with magnetized plasma of mainly solar origin. It extends from the solar corona to well beyond the planets, and is separated from the interstellar medium by the heliopause. The latter is embedded in a complex and still unexplored boundary region. The characteristics of heliospheric plasma, fields, and energetic particles depend on highly variable internal boundary conditions, and also on quasi-stationary external ones. Both galactic cosmic rays and energetic particles of solar and heliospheric origin are subject to intensity variations over individual solar cycles and also from cycle to cycle. Particle propagation is controlled by spatially and temporally varying interplanetary magnetic fields, frozen into the solar wind. An overview is presented of the main heliospheric components and processes, and also of the relevant missions and data sets. Particular attention is given to flux variations over the last few solar cycles, and to extrapolated effects on the terrestrial environment.