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  • 12 - Transcriptomes in schizophrenia: assessing altered gene expression with microarrays

  • Edited by Matcheri S. Keshavan, University of Pittsburgh, James L. Kennedy, Clarke Institute of Psychiatry, Toronto, Robin M. Murray, Institute of Psychiatry, London
  • Book:
    Neurodevelopment and Schizophrenia
    Published online:
    04 August 2010
    Print publication:
    18 November 2004, pp 210-223

  • Summary

    This chapter reviews the current status of the technology to assess transcriptomes, its associated strengths and limitations, and initial findings resulting from the use of the approaches to study schizophrenia. Two types of microarray platform have been used in studies of schizophrenia: complementary DNA (cDNA) microarrays and synthetic oligonucleotide probe arrays. The study of gene expression in human brain tissue, the area of interest in schizophrenia, requires the use of postmortem human brain specimens. In postmortem brain specimens from subjects with schizophrenia, a difference in the expression level of one or a cluster of genes may have several different meanings. The application of transcriptome-based methods to studies of the molecular neuropathology of schizophrenia is clearly in their infancy, and like newborns they offer great promise for the future. However, careful rearing is essential to fulfill this promise.