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1 results

  • The Free Radical Theory of Aging and a Look at Changes in the Hypothalamus

  • J. C. Carlson, M. Sawada
  • Journal:
    Canadian Journal on Aging / La Revue canadienne du vieillissement / Volume 15 / Issue 1 / Spring/printemps 1996
    Published online by Cambridge University Press:
    29 November 2010, pp. 44-53

  • According to the free radical theory, aging is caused by the damaging effects of oxygen radicals. These agents are produced continuously and they become toxic when their intra-cellular levels become elevated. Although well-known for the damage they cause, recent studies indicate that free radicals may also have a beneficial side regulating some of the processes within a cell. With aging, however, it seems that the ability to control endogenous concentrations declines, and rising levels become progressively more harmful. In addition to the primary changes, the effects of free radical damage should also be examined at the secondary level. Because of its importance in regulating homeostatic mechanisms, it is possible that in this regard the hypothalamus may play a crucial role in the aging process. Progressive loss of function in this centre may lead to systemic changes which cause widespread disruption throughout the organism.