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serotonergic agent

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3.15.3 - Overdose, Serotonin Syndrome and Neuroleptic Malignant Syndrome
from Section 3.15 - Psychiatric Disorders Encountered in Intensive Care
- By Ruth Taylor, Peter Byrne
Edited by Ned Gilbert-Kawai, The Royal Liverpool Hospital, Debashish Dutta, Princess Alexandra Hospital NHS Trust, Harlow, Carl Waldmann, Royal Berkshire Hospital, Reading
Book:

Intensive Care Medicine

Published online:

27 July 2023

Print publication:

01 December 2021, pp 441-444
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Summary

Key Learning Points
1. Features of overdose depend on the type of antidepressant or anti-psychotic agent taken.
2. All patients suspected of overdose must be monitored for QRS/QT prolongation.
3. In some overdoses (monoamine oxidase inhibitors, hypoglycaemic agents, long-acting insulin, anticoagulants), onset of symptoms may be delayed; an asymptomatic patient may still require admission and treatment in the intensive care unit.
4. Serotonin syndrome is a medical emergency defined as an adverse reaction to serotonergic agents.
5. Neuroleptic malignant syndrome is a medical emergency caused by an idiosyncratic reaction to neuroleptic medication.