Patients with Alzheimer's Disease (AD) who have reached a stage
of moderate to severe dementia are capable of completing a restricted
range of cognitive tests and performing a limited range of activities of
daily living (ADL). As part of an initiative to develop instruments to
evaluate AD, we analyzed data describing the performance of a large number
of ADL and scores on cognitive and global assessment measures in a cohort
of patients with AD with moderate to severe cognitive impairment, defined
as a Mini-Mental State Examination score ranging from 0–15 (out of
30). From the large pool of ADL, 19 met criteria of applicability,
reliability, good scaling, concordant validity, and sensitivity to detect
change in performance over 6–12 months. A total score derived from
these 19 ADL ratings, comprising a scale termed the Alzheimer Disease
Cooperative Study ADL-sev, correlated strongly with measures of cognition
and of global dementia severity. Patients with moderate to severe AD
showed a decline on the ADL-sev and cognitive measures over 6 and 12
months, consistent with the progression of AD. Detailed evaluation of ADL
may provide a useful index to evaluate patients with moderate to severe AD
and may complement cognitive assessment, especially for characterizing
change in interventional or therapeutic studies. (JINS, 2005,
11, 446–453.)