In their commentaries, Lenzenweger (this volume) and Le and Cohen (this volume) have added important complementary perspectives to understanding and conceptualizing Cluster A disorders.Lenzenweger discusses Cluster A disorders in the context of previous theory and research on schizotypy and schizophrenia, for instance discussing how schizotypy is a distinct construct from Schizotypal Personality Disorder. Le and Cohen focus on situating Cluster A symptomatology in the context of efforts to move beyond traditional DSM categorical personality disorders as well as efforts to develop alternative assessment methods. These are both valuable complementary perspectives to the chapter that was focused primarily on research specifically on DSM Cluster A personality disorder categories.

There is strong evidence that schizotypal PD is a schizophrenia-spectrum disorder and an initial diagnosis of schizotypal PD is a strong predictor of future onset of schizophrenia. Despite this evidence, there are questions about whether schizotypal PD or the other Cluster A disorders as currently diagnosed best reflect traits indicating risk for schizophrenia. Further, it is still not empirically resolved to what extent positive schizotypal symptoms reflect genetic risk for schizophrenia. There is strong evidence that schizotypal PD is related to psychological trauma. At the same time, there is evidence that some schizotypal symptoms do appear to reflect variation on normal personality traits, but it is still unresolved whether and how schizotypal symptoms reflect high levels of openness to experience. Cluster A disorders appear to be more common than often assumed and have been associated with poor functioning, but there is a lack of treatment research on these disorders.