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1 results

  • Genetic Control of the Aging Process: A Review and Interpretation

  • Hildegard E. Enesco
  • Journal:
    Canadian Journal on Aging / La Revue canadienne du vieillissement / Volume 15 / Issue 1 / Spring/printemps 1996
    Published online by Cambridge University Press:
    29 November 2010, pp. 16-30

  • The process of aging is under genetic control. The traditional view derived from evolutionary biology is that aging is a polygenic trait, controlled by a large number of genes, each with a small additive effect. An alternative point of view is presented here, which suggests that there may be only a few master genes that control aging. These could include protective genes that ensure accuracy of protein synthesis and protect against free radical damage, as well as genetic control switches that initiate or delay the aging process. As genetic technology advances and the human genome is mapped, our understanding of genes that control aging and age-related diseases may advance to the point that gene therapy becomes possible.