Scholars have long grappled with the puzzle as to why some regions become peaceful and resilient while others crumble into perpetual insecurity. Much of the scholarship that they produced viewed regional formations as extensions of the state system. This work argues that state-centric tools to study regionalism have precluded us from uncovering regional forms of engagement under hierarchical relations of empires. They have privileged great power politics, at the expense of the political agency of non-state actors, such as minority communities, constitutional assemblies, and political parties, among others. This work highlights the lack of conceptual tools to capture historical continuity in the regional fabric of world politics. The bulk of the article engages in the methodology of concept development for regional fracture, in an effort to advance comparative regional studies historically and systematically. The concept development is then applied in the context of the Eastern Anatolian region of the late Ottoman Empire.