Prostrate water primrose is a troublesome weed in rice paddy fields. A study was conducted to determine the influence of environmental and agronomic factors on its emergence. The efficacy of herbicides on this species was also examined. The germination percentage of mature seeds remained above 90% within 180 d after harvest, indicating a low primary dormancy of this species. Light stimulated seed germination. Seeds buried deeper than 0.5 cm did not form seedlings. These results suggest that stale seedbed practices and deep tillage operations can mitigate the occurrence of this species in paddy fields. The optimum temperature for germination varied from 25/15 C to 35/25 C. The osmotic potential and salt concentration needed to inhibit 50% of maximum germination were −0.4 MPa and 197 mM, respectively. Seeds were tolerant to flooding and did not germinate at pH 8 to 10. The preemergence herbicides oxadiazon, oxadiargyl, and butachlor had excellent control efficacy on prostrate water primrose, with a 95.4% to 100% reduction in seedling number and a 99.2% to 100% reduction in biomass, respectively. The postemergence herbicides MCPA-Na + bentazone, bentazone, MCPA-Na, and fluroxypyr applied at the 2- to 3-leaf stage of prostrate water primrose provided a 90.6% to 100% reduction in seedling number and a 99.3% to 100% reduction in biomass. The results of this study can help in developing sustainable and effective integrated weed management strategies for controlling prostrate water primrose in paddy fields.