Field studies were conducted for 3 yr to determine weed and potato response to preemergence (PRE) and postemergence (POST) applications of rimsulfuron, metribuzin, and rimsulfuron plus metribuzin. Preemergence applications of rimsulfuron at 27 g ai/ha and POST applications at 18 g/ha controlled barnyardgrass, redroot pigweed, and wild buckwheat. Common lambsquarters was controlled by PRE or POST applications of metribuzin or a tank mixture of 18 g/ha rimsulfuron plus 140 g ai/ha of metribuzin. ‘Russet Burbank’ potato was relatively tolerant to all rimsulfuron, metribuzin, and rimsulfuron plus metribuzin applications, and potato yield was not reduced compared to the hand-weeded control.