Weed control and potato response to halosulfuron applied alone POST and with rimsulfuron or S-ethyl dipropyl carbamothioate (EPTC) were evaluated in 2004 and 2005 near Paterson, WA. Potatoes were injured and exhibited chlorosis and stunted growth after halosulfuron applications of 18, 26, and 35 g/ha. Potato height was reduced 33 and 20% in late May by halosulfuron at 18 or 26 g/ha in 2004 and 2005, respectively. Halosulfuron applied alone failed to control hairy nightshade and large crabgrass. Total tuber yield and U.S. no. 1 yield were reduced 10% in halosulfuron-treated plots because of poor weed control and possibly herbicide injury. Tank-mixing rimsulfuron with halosulfuron improved control of hairy nightshade and large crabgrass and increased potato yield. Tank-mixing EPTC at 2 kg/ha with halosulfuron improved early-season hairy nightshade control, but weed control was poor at row closure. Rimsulfuron applied alone at 18 or 26 g/ha controlled hairy nightshade and large crabgrass without potato injury and resulted in the greatest potato yields.