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1 results

  • Chapter 16 - Plasma Cell Neoplasia

  • Jon van der Walt, Attilio Orazi, Daniel A. Arber, University of Chicago
  • Book:
    Diagnostic Bone Marrow Haematopathology
    Published online:
    12 November 2020
    Print publication:
    21 January 2021, pp 283-297

  • Summary

    Plasma cell neoplasms are derived from mature, IG heavy chain class-switched terminally differentiated B-cells, which usually secrete a monoclonal immunoglobulin or M-protein and consist of a homogeneous population of neoplastic plasma cells [1]. Plasma cell myeloma (PCM) is a common malignancy, manifesting itself by bone marrow (BM) infiltration and bone destruction, and therefore representing an entity frequently encountered in BM biopsies(BMB). Its precursor lesion, non-IgM monoclonal gammopathy of unknown significance (MGUS) is a frequent finding in elderly individuals and shows a low, but definite risk for progression to PCM. In this chapter, we will discuss the diagnosis and differential diagnosis of PCM, MGUS and clonal plasma cell disorders with associated paraneoplastic syndromes, including POEMS syndrome and TEMPI syndrome. Amyloidosis is discussed in Chapter 3, and other mature B-cell neoplasms with a clonal plasma cell component in Chapter 15.