Loblolly pine or slash pine response and vegetation colonization are summarized for a region-wide study that included five locations on coastal soils in the southern United States. The objective was to evaluate timing of postplant herbaceous weed control (HWC) treatments following preplant site preparation with imazapyr applied at two timings (August and November) and at three rates (0.56, 0.84, and 1.12 kg ha−1). All imazapyr site preparation treatments were applied after bedding. Site preparation treatments resulted in fast-growing stands without HWC at all locations with average Year 3 dominant tree height ranging from 2.6 to 3.7 m. Imazapyr plus sulfometuron was an effective HWC treatment on loblolly pine. Vegetation control and pine response varied by surface soil texture. On coarser-textured soils, the site preparation treatments resulted in <10% vegetation cover in June of the first pine growing season. On these coarser-textured soils, loblolly pine growth was increased by second-year and not first-year HWC. On finer-textured soils, vegetation colonization was aggressive, with >20% cover in June of the first pine growing season, such that early first-year HWC provided the largest loblolly pine response of single-pass HWC treatments. Pines were highly tolerant to imazapyr site preparation treatments as evidenced by the lack of differences in slash or loblolly pine survival and growth from the doubling of imazapyr rates for applications in either August or November. There was little meaningful residual control of herbaceous vegetation into the second pine growing season from site preparation treatments or first-year HWC regardless of location. There was no consistent pine response benefit from increasing the imazapyr site preparation rate for included treatments. Cost-effective treatments would utilize low site-preparation herbicide rates followed by the appropriate timing of HWC if longer-term vegetation control is the objective.