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The importance of the insula in focal epilepsy is increasingly being recognized. As such, surgical procedures involving the insula and their associated risks, especially vascular complications, are under investigation. Understanding of vascularization of the insula is essential for performing safe and accurate surgical treatment. This chapter summarizes the vascularization of the insula and related structures, including the M1, M2, and M3 segments of the middle cerebral artery, lenticulostriate artery, and long insular artery (LIA). The LIA is especially important to identify to avoid a white matter motor tract infarction during insular surgery. In addition, the venous system of the insula is described.
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