Various combinations of methods were evaluated for the control of ivyleaf morningglory growing in cotton. The combinations included chemicals incorporated to two depths or tanked-mixed as postemergence treatments and cultural methods that included in-row cultivation and hand weeding. The most effective combinations of methods included a herbicide such as cyanazine or prometryn in some treatments resulting in reduced ivyleaf morningglory population and improved cotton yields. Cultural methods without chemical assistance gave little or no control of ivyleaf morningglory based on weed populations and cotton yield. Statistically the best combinations had lint yields equal to the weed-free treatment, but the yields were reduced from 114 to 372 kg/ha. Also, most combination treatments had enough plant debris in the lint to reduce fiber grade.