Partisans have biased perceptions of objective conditions. At first glance, the COVID-19 pandemic would appear to be an example of this phenomenon. Noting that most citizens have consistently agreed about the pandemic, I argue that we have overlooked pre-political factors that are as influential as partisanship in shaping citizens’ responses to the pandemic. I identify one such construct in perceived vulnerability to infectious disease (PVD). In one cross-sectional study and one panel study, I find that the influence of PVD on citizens’ perceptions of COVID-19 equals that of partisanship. I also find that PVD can moderate the influence of partisanship on perceptions of harmfulness, nearly erasing the impact of being a Republican on perceiving COVID-19 as a threat. When led by PVD as well as partisanship to accurately perceive harm, citizens, including Republicans, attribute more responsibility to former president Donald Trump for his failed handling of the crisis.