We investigate the groups of units of one-relator and special inverse monoids. These are inverse monoids which are defined by presentations, where all the defining relations are of the form $r=1$. We develop new approaches for finding presentations for the group of units of a special inverse monoid, and apply these methods to give conditions under which the group admits a presentation with the same number of defining relations as the monoid. In particular, our results give sufficient conditions for the group of units of a one-relator inverse monoid to be a one-relator group. When these conditions are satisfied, these results give inverse semigroup theoretic analogues of classical results of Adjan for one-relator monoids, and Makanin for special monoids. In contrast, we show that in general these classical results do not hold for one-relator and special inverse monoids. In particular, we show that there exists a one-relator special inverse monoid whose group of units is not a one-relator group (with respect to any generating set), and we show that there exists a finitely presented special inverse monoid whose group of units is not finitely presented.