The evolution of herbicide-resistant weeds has resulted in the necessity to integrate nonchemical control methods with chemicals for effective management in crop production systems. In soybean, control of the pigweed species, particularly herbicide-resistant waterhemp and Palmer amaranth, have become predominant concerns. Cereal rye planted as a winter cover crop can effectively suppress early-season weed emergence in soybean, including waterhemp, when planted at a rate of 123 kg ha−1. The objectives of this study were to determine the effects of different cereal rye seeding rates (0, 34, 56, 79, 110, and 123 kg ha−1) on early-season waterhemp suppression and soybean growth and yield. Soybean was planted into fall-seeded cereal rye, which was terminated within 4 d of soybean planting. The experiment was conducted over the 2018, 2019, and 2020 growing seasons in Columbia, Missouri. Effects of cereal rye on early-season waterhemp suppression varied by year and were most consistent at 56 kg ha−1 or higher seeding rates. Linear regression analysis of cereal rye biomass, height, or stand at soybean planting showed inverse relationships with waterhemp emergence. No adverse effects on soybean growth or yield were observed at any of the cereal rye seeding rates relative to plots that lacked cereal rye cover. Result differences among the years suggest that the successfulness of cereal rye on suppression of early-season waterhemp emergence is likely influenced by the amount of waterhemp seed present in the soil seed bank.