Following the opening of the Suez Canal in 1869, long-distance pilgrimage to Islamic holy sites expanded and quickened, resulting in the spread of cholera among travelers. The necessity of taking circuitous routes to holy cities both inside and outside Iran significantly exacerbated the spread of cholera. Although potential factors such as inadequate public health infrastructure and ineffective quarantine measures contributed to the dissemination of cholera, overall religious mobility in the form of pilgrimage primarily factored behind cholera's spread. Analyzing the influence of religious mobility and rituals sheds light on how pilgrims, as contagions, dealt with the pandemic and the treatment they received from authorities, members of host societies, and individuals within and outside Iran during the cholera pandemics of the1890s and early 1900s.