The successful integration of immigrant-origin youth is a highly important issue for multiple stakeholders in many countries. It has important benefits both to countries of destination and countries of origin, as well as to immigrants and nonimmigrants. In this article, I examine immigrant-youth adaptation through the lens of a recently developed resilience model integrating acculturation and social psychological influences on adaptation. Who among immigrant-origin youth adapt well, academically, and socially, in the Greek school context? What is the role of acculturation in immigrant youth resilience? These questions are addressed using scientific evidence drawn from the Athena Studies of Resilient Adaptation (AStRA) project, a three-cohort, three-wave longitudinal project on immigrant-origin youth adaptation conducted in Greece, as well as from the international literature. Following an anti-racist research approach to understanding the AstRA findings, I will argue that the lived school experiences of immigrant-origin youth may be a reflection of societal-level xenophobic and anti-immigrant attitudes. Such systemic and structural racism is the key determinant of the difficulties they face in their adaptation. The findings presented reveal the need to promote an equitable and inclusive education that will be beneficial for all students promoting their well-being, and their sense of belonging to school and society.