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1 results

  • Chapter 10 - Tubulointerstitial Diseases with Crystal and Pigment Deposits

  • from Section 3 - Tubulointerstitial Diseases
  • Edited by Helen Liapis, Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
  • Book:
    Pediatric Nephropathology & Childhood Kidney Tumors
    Published online:
    10 August 2023
    Print publication:
    09 March 2023, pp 197-212

  • Summary

    Tubulointerstitial diseases with crystal and pigment deposits are important histopathological disease entities that occur in pediatric patients and that are associated with acute and chronic kidney injury. Tubulointerstitial diseases with crystal deposits include oxalate nephropathy, nephrocalcinosis and 2,8-dihydroxyadenine (DHA) nephropathy. Tubulointerstitial diseases with pigment deposits include myoglobin cast nephropathy, hemoglobin cast nephropathy, red blood cell casts and bile cast nephropathy.

    Although some of these tubulointerstitial diseases may show overlapping histopathological features, it is important to distinguish them as separate entities, since each of them is associated with distinct clinical symptoms, etiologies, therapies and prognosis.