In this paper, central limit theorems for multivariate semi-Markov sequences and processes are obtained, both as the number of jumps of the associated Markov chain tends to infinity and, if appropriate, as the time for which the process has been running tends to infinity. The theorems are widely applicable since many functions defined on Markov or semi-Markov processes can be analysed by exploiting appropriate embedded multivariate semi-Markov sequences. An application to a problem in ion channel modelling is described in detail. Other applications, including to multivariate stationary reward processes, counting processes associated with Markov renewal processes, the interpretation of Markov chain Monte Carlo runs and statistical inference on semi-Markov models are briefly outlined.
