It is believed that the attentional engagement of language learners may reinforce deeper neuronal processing and promote later retrieval. To address language learners’ needs and facilitate language learning, we used audio-visual entertainment (AVE) and cranio-electro stimulation (CES), in addition to multisensory-based instruction, to modify attention and retention processes. Thus, we taught a set of words with the common procedure of audio-visual instruction to 32 English language learners in the control group, CES, and AVE sessions. However, they received five sensory involvements (i.e., auditory, visual, tactile, olfactory, and gustatory) for the target words in the multisensory session. Following each instruction, a pragmatic-Stroop task and a true/false test were conducted to examine the subjects’ attention and retention processes, respectively. Analyzing the response times acquired from the pragmatic-Stroop task, it was found that multisensory-based instruction led to quicker responses in comparison to the audio-visual method preceded by AVE and CES stimulations. The response accuracy results from the retention test also revealed that the subjects provided more accurate responses to the words taught during the multisensory session. The implication is that the enriched multisensory inputs can improve L2 learners’ mental agility and facilitate successful retention and retrieval of information after a short interval period.