The Quality of Life (QoL) in psychiatric patients is currently of great relevance. This study aims to examine, through a multi-informant approach, the QoL perception in schizophrenic patients, analyzing differences between the informants, as well as the relationship between negative symptoms and QoL. Participants were 32 schizophrenic patients, their caregivers (relatives or psychosocial educators; 25 and 3, respectively), and a team of four professionals of Outpatient Centers of Mental Health in Guipuzcoa, Spain. The assessment of patients’ QoL was obtained with application of Satisfaction with Life Domains Scale and Karnofsky Performance Status Scale. Self-informant QoL was assessed with Seville Quality of Life Questionnaire and Social Adjustment Scale Self-reported. The negative symptoms were measured with the Brief Psychiatric Rating Scale and the Scale for Assessment of Negative Symptoms. Patients showed an average high life satisfaction. There were significant discrepancies among informants’ reports, with the lowest evaluation given by the professional team and the highest by the patients. Evaluations made by caregivers and patients yielded similar results. These findings suggest that patients and their caregivers present a more optimistic perception of their QoL.