The graphical user interface was introduced to democratize access to computer systems by simplifying hardware and visual interfaces. Technological advancements further reduced the constraints, primarily benefiting the mainstream users. However, the specialized needs of the critical users have always been neglected. This paper delves into the ergonomics of the mouse pointer and the computer mouse, focusing on left-handed computer users as a critical user category to develop and propose a universal design solution to integrate left-handers as a mainstream user category in a computer interface.