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A mixed-effects location scale model allows researchers to study within- and between-person variation in repeated measures. Key components of the model include separate variance models to study predictors of the within-person variance, as well as predictors of the between-person variance of a random effect, such as a random intercept. In this paper, a latent variable mixed-effects location scale model is developed that combines a longitudinal common factor model and a mixed-effects location scale model to characterize within- and between-person variation in a common factor. The model is illustrated using daily reports of positive affect and daily stressors for a large sample of adult women.
This article explores intraindividual microvariation in dialect syntax. We argue that in many cases the speaker has internalized a different (sub)grammar for each dialectal variety, in line with the hypothesis of universal bilingualism and parallel grammars argued for by Roeper (1999 et seq.). We discuss the question of how we can distinguish parallel grammars from optionality within one grammar, suggesting that the identification of correlating contextual factors might be a promising criterion. However, we also explore a more subtle type of variation, namely cases where a standard variety influences a potentially more vulnerable non-standard variety in a way that makes it exceedingly difficult for the language user and even for a trained linguist to discern what is what. We discuss whether or not these properties should be analysed as properties of another subgrammar (the standard grammar) or as fully integrated (albeit acquired) properties of the non-standard dialect.
By
Vural Ozdemir, Centre for Addiction and Mental Health, University of Toronto, Canada; Department of Pharmacology, University of Toronto, Canada,
Angela D.M. Kashuba, School of Pharmacy, University of North Carolina, Chapel Hill, USA,
Vincenzo S. Basile, Centre for Addiction and Mental Health, University of Toronto, Canada,
James L. Kennedy, Centre for Addiction and Mental Health, University of Toronto, Canada
Edited by
Bernard Lerer, Hadassah-Hebrew Medical Center, Jerusalem
Drug metabolism is a critical determinant of therapeutic and adverse effects of many psychotropic drugs. This chapter reviews the basic concepts and definitions pertinent to pharmacogenetics of psychotropic drug metabolism from a clinical psychiatry perspective. It discusses the CYP2D6 genetic polymorphism as a classic example of a monogenic variation in drug metabolism and as a high-affinity and low-capacity elimination route. In addition to genetic contribution to interindividual differences in drug metabolism, the chapter reviews various sources of intraindividual variations and gene-environment interactions of relevance for psychopharmacology. It highlights some of the future research directions in psychotropic drug metabolism and emphasizes the need to evaluate genetic variability in drug metabolism in conjunction with other genes encoding drug transporters, receptors and ion channels, which can all influence individual's risk for adverse drug reactions or therapeutic failure.
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