This article discusses Africa’s deepening marginalization in the globalization of production, finance, and labor. It underscores critical development issues that result from, and are exacerbated by, globalization in the context of unequal global distribution of economic and political power: illicit financial flows and tax evasion, the brain drain, an increasing incidence of noncommunicable diseases, and the disproportionate burden of environmental degradation that is shouldered by the African continent. It also offers some policy suggestions to address these issues at national and regional levels.