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  • 2 - Rethinking Psychiatric Disorders in Terms of Heterarchical Networks of Control Mechanisms

  • from Section 1
  • Edited by Kenneth S. Kendler, Virginia Commonwealth University, Josef Parnas, University of Copenhagen, Peter Zachar, Auburn University, Montgomery
  • Book:
    Levels of Analysis in Psychopathology
    Published online:
    02 April 2020
    Print publication:
    02 April 2020, pp 24-46

  • Summary

    This chapter offers a framework for understanding mechanistic explanations of psychiatric disorders in terms of altered activities in a heterarchical network of control mechanisms. This differs both from approaches that seek to characterize the mechanism responsible for producing the disease state and those that attribute the disease state to broken mechanisms. Control mechanisms operate on soft constraints in other mechanisms and thereby alter their operation. Although often viewed as hierarchical, the brain is organized as a heterarchical network, with many control mechanisms operating on the same controlled mechanisms and no chief executive. This poses challenges for attempts to understand the ramifications of altered functioning of components of the network. Using a recent example of research showing the effects of modifying the activity of proteins within the circadian clock on depression-like behavior in mice, this chapter illustrates how progress might be made as well as the challenges faced in explaining psychiatric disorders.