The common-sense model of self-regulation delineates cognitive and emotional processes influencing motivations to engage in adaptive behaviors. Originally developed to account for reactions to health-related threats, the common-sense model also holds utility for interventions to change behavior in other domains involving threats to performance and well-being. This chapter provides an overview of the common-sense model and how specific mechanisms such as threat representations, emotion regulation processes, imagery processes, and appraisal processes influence behaviors. The chapter reviews research on approaches for eliciting behavior change through psychoeducational approaches, communication skills training for practitioners, communications arousing worry and fear, training in emotion regulation skills, action planning, and appraisal skills. Specific behavior change strategies (e.g., fear arousal, action planning, self-monitoring) have been tested extensively, although studies testing interventions specifically guided by the common-sense model and targeting multiple model components remain limited. The chapter concludes with considerations of future directions for intervention developments and research on applying the model to promote adaptive behaviors in multiple life domains.