Science shows mounting global health risks associated with plastics life cycle pollution. Leveraging evidence and streamlining research to inform policy is critical to safeguarding people and planet. We conducted an electronic survey questionnaire, between 16th April and 16th August 2024, amongst United Nations government delegates developing the Global Plastics Treaty. We explored (1) perceptions and prioritisation of human health evidence, (2) preferred plastic pollution mitigation strategies, and (3) priorities for health research. Responses were collected in Qualtrics and analysed using summary statistics, the Fisher’s Exact Test, and thematically mapped to the Policy Cycle Framework. We received 27 survey responses, balanced by gender and career stage, including 23 countries and all World Bank country income classifications and regions, but greater representation from high-income and European countries. Human health was the highest-ranking concern related to plastics risks (Sum of rank scores (SRS) = 54). Most delegates expressed strong conviction in evidence of risks associated with plastics chemicals, polymers, products, microplastics and broader life cycle emissions. Reducing plastics production (SRS = 53) and eliminating chemicals, polymers and products of concern (SRS = 53) were prioritised, even amongst those affiliated with waste management departments or less convinced of health risks. We found the least regard for recycling as a strategy to protect health (SRS = 4–5) and eliminating open burning was the most prioritised downstream measure (SRS = 15). Generating quantitative, causal data on risks across plastics life cycles, identifying emerging health hazards, defining criteria, safe lists and substitutes for chemicals, polymers and products were government delegate priorities for research, alongside tools to track policy impacts on health and greater bilateral communication between scientists and delegations. Health risks of all forms of plastic pollution were a concern for most delegates responding to our survey. We identified key priorities for policy-driven research to strengthen the science-policy interface and support evidence-based plastics policy that protects human health.