The Cuban Revolution of 1959 ushered in many radical changes, both socio-economic and political. Yet the macropolitical upheaval of the period also manifested in concrete ways in the lives of ordinary Cubans. The sudden scarcity of everyday medications, closely linked to diplomatic tensions with the United States, was one such outcome. This article traces the transnational battles provoked by the sudden disappearance of US prescription drugs from Cuban shelves. It seeks to understand pharmaceutical shortages not only as a political side effect but also as a social reality, which provided a venue for the articulation of new forms of sociability and body politics.