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An engineered class I transfer RNA with a class II tertiary fold
T. AMAR NISSAN, BRYANT OLIPHANT, JOHN J. PERONA
Journal:

RNA / Volume 5 / Issue 3 / March 1999

Published online by Cambridge University Press:

01 March 1999, pp. 434-445

Print publication:

March 1999
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Structure-based engineering of the tertiary fold of Escherichia coli tRNA2Gln has enabled conversion of this transfer RNA to a class II structure while retaining recognition properties of a class I glutamine tRNA. The new tRNA possesses the 20-nt variable stem-loop of Thermus thermophilus tRNASer. Enlargement of the D-loop appears essential to maintaining a stable tertiary structure in this species, while rearrangement of a base triple in the augmented D-stem is critical for efficient glutaminylation. These data provide new insight into structural determinants distinguishing the class I and class II tRNA folds, and demonstrate a marked sensitivity of glutaminyl-tRNA synthetase to alteration of tRNA tertiary structure.