Experiments were conducted to investigate the interactions of tank-mix combinations of sethoxydim plus the sodium salt of bentazon, the sodium salt of acifluorfen, fomesafen, imazaquin, or the ethyl ester of chlorimuron. Antagonistic interactions were observed with tank-mixes of sethoxydim plus bentazon, imazaquin, or chlorimuron applied for fall panicum, large crabgrass, and goosegrass control in field experiments. Antagonism was observed in greenhouse experiments with tank-mixes of sethoxydim plus bentazon or imazaquin applied to goosegrass. Bentazon, acifluorfen, and fomesafen reduced 14C-sethoxydim uptake by large crabgrass. However, imazaquin and chlorimuron did not affect 14C-sethoxydim uptake. In field experiments, no interactions occurred with tank-mixes of sethoxydim plus any of the broadleaf weed control herbicides applied to entireleaf or tall morningglory.