Field trials were conducted from 1991 to 1993 in the northern cotton-producing area of Alabama to evaluate the interaction of various production inputs for pest management and cotton development, maturity, and yield. Two levels of tillage (conventional and no-till), herbicide (1.12 and 2.24 kg ai ha−1 fluometuron, preemergence, with post-directed herbicides), insecticide (0.5 and 0.85 kg ai ha−1 aldicarb, in-furrow), and fungicide (0.9 kg ai ha−1 quintozene plus ethridazole, in-furrow or 0.14 kg ai ha−1 metalaxyl, hopper-box) programs were evaluated. The inputs investigated did not interact significantly to change the overall production strategy. Prickly sida required a higher level of herbicide input than did the entireleaf/ivyleaf morningglory complex. Both species were sufficiently controlled using reduced levels of fluometuron without sacrificing yield; however, cultivation was necessary in conventional tillage treatments to maintain control. A postemergence-directed herbicide treatment was also necessary for weed control, regardless of tillage. Decreasing the levels of each input simultaneously did not interact to affect cotton stand, height, early-season thrips counts, cotton maturity, or yield. Cotton was shorter in no-till than conventional plots.