This introductory article describes the content of the October 2004 issue of MRS Bulletin focusing on novel materials and applications of electronic noses and tongues.The articles in this issue review the state of the art in materials, devices, and data processing algorithms used in electronic olfaction and taste systems. The most common gas- and liquid-phase analyte detection tools are presented and compared with traditional chemical analysis instrumentation such as gas chromatography/mass spectroscopy systems. Metal oxides, polymer/polymer composites, and dyes are covered in these articles as key sensing materials. Resistive, optical, electrochemical, and other types of electronic nose and tongue systems are reviewed, and their use in diverse applications, including environmental and food-quality monitoring and medical diagnostics, is discussed.