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1 results

  • Systematic review and meta-analysis on the role of mitochondrial cytochrome c oxidase in Alzheimer’s disease

  • Flavio M. Morais, Angela M. Ribeiro, Fabricio A. Moreira, Pollyanna V. G. Silva
  • Journal:
    Acta Neuropsychiatrica / Volume 33 / Issue 2 / April 2021
    Published online by Cambridge University Press:
    01 December 2020, pp. 55-64
  • Objective:

    The present study was designed to test the hypothesis that there is a reduction in the activity of the enzyme cytochrome c oxidase (Cox) in Alzheimer’s disease (AD).

    Methods:

    Systematic review of literature and meta-analysis were used with data obtained from the PubMed, Scopus, MEDLINE, Lilacs, Eric and Cochrane. The keywords were Alzheimer’s AND Cox AND mitochondria; Alzheimer’s AND Cox AND mitochondria; Alzheimer’s AND complex IV AND mitochondria. A total of 1372 articles were found, 23 of them fitting the inclusion criteria. The data were assembled in an Excel spreadsheet and analysed using the RevMan software. A random effects model was adopted to the estimative of the effect.

    Results:

    The data shows a significant decrease in the activity of the Cox AD patients and animal models.

    Conclusion:

    Cox enzyme may be an important molecular component involved in the mechanisms underlying AD. Therefore, this enzyme may represent a possible new biomarker for the disease as a complementary diagnosis and a new treatment target for AD.