Gravid Lucilia treated topically with ivermectin (0.05μg/g, which represented approx. 4% of the 48 hr LD50) laid fewer viable egg batches (less than 50% of controls) and more sterile ones, when compared to untreated (P = 0.019) and acetone-treated flies (P = 0.028). This effect was also seen when mature third instar larvae were dosed with 7.6 μ g ivermectin/g (P = 0.0075 and 0.016 respectively); number of viable egg batches produced were only 25% of the number laid by the progeny of untreated larvae.
Dosage with fenthion stimulated an increase in the number of viable egg batches laid when incorporated in the original larval feeding medium at 0.2 μg/g liver; fewer viable egg batches were laid by the flies which developed from mature larvae treated with 7.6 μ g fenthion/g. Acetone solvent alone had a mild stimulatory effect on topically dosed flies.
