This paper presents a Ka-band series single-pole double-throw (SPDT) switch circuit realized in substrate-integrated coaxial line (SICL) environment for time division duplex operation. It is designed with a low-cost printed circuit board (PCB) technique. The size of the proposed circuit is $3.1\lambda_{g} \times 5.9\lambda_{g}$, where λg is the guided wavelength at the center frequency of 27.75 GHz. In this circuit, a SICL-based SPDT switching circuit is proposed with radio frequency (RF) isolation network where the shunt connection of butterfly stubs is in an asymmetric stripline environment. The proposed circuit exhibits less than 2 dB insertion loss at 27–27.9 GHz and less than 2.5 dB insertion loss at 27–28.5 GHz. The design offers good impedance matching in the Transmit (Tx) and Receive (Rx) channels from the common Tx/Rx input channel, along with more than 24 dB isolation between ON and OFF state output channels. The proposed circuit is suitable for millimeter-wave communication systems.