Tolerance of six soft red winter wheat cultivars to AE F130060 00 plus AE F115008 00 applied at 12.5 plus 2.5 g ai/ha and 25 plus 5 g ai/ha, respectively, at the two- to three-tiller stage was examined under weed-free conditions at four locations over 2 yr. Visible injury averaged 5 and 15% 3 wk after treatment (WAT) in years 1 and 2, respectively. Injury was 2% or less 10 WAT. No differences among cultivars were noted for visible injury, and AE F130060 00 plus AE F115008 00 did not reduce grain yield in year 1. In year 2, averaged over herbicide rates, grain yields of the cultivars ‘Coker 9663’, ‘Pioneer 2580’, ‘Coker 9704’, ‘Pioneer 2684’, ‘FFR 555’, and ‘Jackson’ were reduced 3, 5, 6, 8, 10, and 16%, respectively. The yield reduction for Jackson was different from those for the other cultivars. Yield reduction was attributed to reduced numbers of kernels per spike.